AMY1C, amylase alpha 1C, 278

N. diseases: 63; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.050 Biomarker group BEFREE The change of sAA after stroop test in GAD patients can predict the severity of anxiety, but subjective psychological perception can not. 31726179 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.050 Biomarker group BEFREE We examined physiological stress responses (cortisol and salivary alpha-amylase [sAA]), negative emotional stress responses (anxiety and self-conscious emotions), and post-task ruminative thoughts. 30265076 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.050 Biomarker group BEFREE We examined physiological stress responses (cortisol and salivary alpha-amylase [sAA]), negative emotional stress responses (anxiety and self-conscious emotions), and post-task ruminative thoughts. 31497984 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.050 AlteredExpression group BEFREE The following outcomes will be recorded: completion of dental treatment, anxiety scores at baseline and after treatment using Frankl rating behavior scale and physiological anxiety related changes will be recorded using salivary Alpha Amylase and Cortisol levels. 31464945 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.050 Biomarker group BEFREE <b>Methods:</b> Salivary α-amylase (sAA), galvanic skin response (GSR) and anxiety were assessed over a 2-h operating flight. 29867525 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE We identified a panel of three protein biomarkers, salivary alpha amylase (AMY1), Flt3 ligand (FLT3L), and monocyte chemotactic protein 1 (MCP1), which are upregulated in human patients receiving fractionated doses of total body irradiation (TBI) therapy as a treatment for cancer. 30605362 2020
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE Emotion regulation and positive affect in the context of salivary alpha-amylase response to pain in children with cancer. 29350481 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 AlteredExpression group BEFREE On the basis of these results, the clinical occurrence of amylase-producing cancer likely relates to the tissues expressing the AMY1 gene, while the AMY2B gene, which evolutionarily is the oldest gene among human amylase isogenes, is constitutively expressed in various tissues. 7507116 1994
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 AlteredExpression group BEFREE On the basis of these results, the clinical occurrence of amylase-producing cancer likely relates to the tissues expressing the AMY1 gene, while the AMY2B gene, which evolutionarily is the oldest gene among human amylase isogenes, is constitutively expressed in various tissues. 7507116 1994
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 Biomarker group BEFREE We identified a panel of three protein biomarkers, salivary alpha amylase (AMY1), Flt3 ligand (FLT3L), and monocyte chemotactic protein 1 (MCP1), which are upregulated in human patients receiving fractionated doses of total body irradiation (TBI) therapy as a treatment for cancer. 30605362 2020
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 Biomarker group BEFREE Emotion regulation and positive affect in the context of salivary alpha-amylase response to pain in children with cancer. 29350481 2018
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.010 Biomarker group BEFREE The possibility of HSGA should be considered when an adenocarcinoma producing human salivary alpha-amylase is diagnosed away from sites where major and minor salivary glands normally are found. 9258723 1997
CUI: C0013146
Disease: Drug abuse
Drug abuse
0.010 Biomarker group BEFREE There was also a positive correlation between sAA reactivity and the CTQ subscales of childhood physical abuse (r = .46, p = .005) and emotional abuse (r = .37, p = .024). 27577885 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.010 Biomarker group BEFREE Areas under the receiver operator characteristic analysis revealed that the cutoff values of salivary alpha-amylase for identifying moderate-severe OSA and OSA concomitant hypertension were 17.64 U/mL (sensitivity 85%, specificity 91%) and 25.35 U/mL (sensitivity 70%, specificity 94%), respectively. 31126512 2019
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 AlteredExpression group BEFREE The results indicated that the parotid gland and hepatoma (also liver) clearly expressed AMY 1 and AMY 2B genes, respectively. 12104089 2002
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases
0.010 Biomarker group BEFREE Batch injection analysis towards auxiliary diagnosis of periodontal diseases based on indirect amperometric detection of salivary α-amylase on a cupric oxide electrode. 30340690 2018
CUI: C0032002
Disease: Pituitary Diseases
Pituitary Diseases
0.010 Biomarker group BEFREE Here, a study protocol is presented that allows the assessment of associations between music listening and psychobiological stress in daily life by noninvasively measuring salivary cortisol (as a marker of the Hypothalamic-Pituitary-Adrenal (HPA) axis) and salivary alpha-amylase (as a marker of the Autonomic Nervous System (ANS)). 28190047 2017
CUI: C0039494
Disease: Temporomandibular Joint Disorders
Temporomandibular Joint Disorders
0.010 Biomarker group BEFREE No significant differences were observed in the salivary cortisol area under the curve (AUCG mean ± SD = 90.22 ± 63.36 × 94.21 ± 63.13 µg/dL/min) and sAA AUCG (mean ± SD = 2544.52 ± 2142.00 × 2054.03 ± 1046.89 U/mL/min) between the TMD and control groups, respectively (p > 0.05); however, the clinical groups differed in social anxiety domain (t = 3.759; CI = 2.609, 8.496), separation/panic (t = 2.243; CI = 0.309, 5.217), physical symptoms (U = 433.500), and MASC total score (t = -3.527; CI = -23.062, -6.412), with a power of the test >80% and large effect size (d = 0.80), with no significant correlation between the MASC total score, cortisol, and sAA levels. 29019550 2017
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders
0.010 Biomarker group BEFREE In this follow-up article, the effects of strategic caffeine administration on the previously reported diurnal profiles of sAA and performance, and the association between sAA and neurobehavioural performance were investigated. 29402402 2019
CUI: C0524528
Disease: Pervasive Development Disorder
Pervasive Development Disorder
0.010 AlteredExpression group BEFREE Not only do these results confirm the stress-reducing nature of two types of multisensory therapy, but they support the use of sAA as a potential tool for evaluating stress levels in individuals with intellectual disability and autism spectrum disorder, providing an important physiological lens that may guide strategies in clinical and non-clinical care for individuals with disabilities. 29159888 2018
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.010 AlteredExpression group BEFREE Not only do these results confirm the stress-reducing nature of two types of multisensory therapy, but they support the use of sAA as a potential tool for evaluating stress levels in individuals with intellectual disability and autism spectrum disorder, providing an important physiological lens that may guide strategies in clinical and non-clinical care for individuals with disabilities. 29159888 2018
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.020 Biomarker phenotype BEFREE Child depression has been inconsistency linked to cortisol and salivary alpha-amylase (sAA) reactivity. 31707039 2020
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.020 AlteredExpression phenotype BEFREE Elevated salivary alpha-amylase levels at awakening in patients with depression. 30005283 2018
CUI: C0730557
Disease: Emotional abuse
Emotional abuse
0.020 Biomarker phenotype BEFREE There was also a positive correlation between sAA reactivity and the CTQ subscales of childhood physical abuse (r = .46, p = .005) and emotional abuse (r = .37, p = .024). 27577885 2017
CUI: C0730557
Disease: Emotional abuse
Emotional abuse
0.020 Biomarker phenotype BEFREE We tested whether EA moderated the relation between fractional anisotropy (FA), a measure of white matter fiber structure, and sAA. 29740273 2018